Information on Funding
July 18, 2001

Although the focus of the CRISP database is in providing information on scientific research, funding information is also available on various NIH sites.

If general information is needed on funding for specific diseases, consult the Office of Financial Management's website - www4.od.nih.gov/ofm/

To obtain funding information on specific grants, first go to the Awards page of the Office of Extramural Research's website - grants.nih.gov/grants/award/award.htm

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EXERCISE INTOLERANCE IN CHRONIC FATIGUE
Grant Number: 5M01RR00425-290573
PI Name: SWANSON, WILLIAM H.
PI Title:
Project Title: EXERCISE INTOLERANCE IN CHRONIC FATIGUE

Abstract:
To characterize acute cardiorespiratory responses to exercise in patients with CFS and correlate these responses to patient's clinical features and activity patterns; to determine muscular work efficiency in CFS; to determine the physiologic effect of preconditioning with an exercise stress on subsequent cardiorespiratory and muscular responses to exercise and to determine if performance of exercise stimulates an acute phase response in patients with Chronic Fatigue Syndrome.

Thesaurus Terms:
cardiovascular function, chronic fatigue syndrome, exercise, physiologic stressor, injury / disease stressor, muscle function, clinical research, human subject

Institution: HARBOR-UCLA RESEARCH & EDUC INST AT HARBOR-UCLA MEDICAL CENTER TORRANCE, CA 90502
Fiscal Year: 1998
Department:
Project Start: 01-DEC-77
Project End: 30-NOV-01
ICD: NATIONAL CENTER FOR RESEARCH RESOURCES
IRG: RIRG

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ESTIMATING RATES OF CFS IN A COMMUNITY SAMPLE

Grant Number: 5R01AI036295-05
PI Name: JASON, LEONARD A.
PI Title: PROFESSOR
Project Title: ESTIMATING RATES OF CFS IN A COMMUNITY SAMPLE

Abstract: Epidemiologic characterizations of the prevalence of Chronic Fatigue Syndrome are derived largely from data collected in treated populations, and these findings might be biased by differential access to health care treatment by gender, racial/ethnic and social class status. The goal of this study is to do a community-based prevalence study. the specific aims are: 1) to determine the rate of CFS in a socioeconomically and ethnically diverse sample 26,000 adults in Chicago; 2) to establish the relative prevalence of CFS across race/ethnicity, socioeconomic status and gender; and 3) to examine comorbidity between CFS and psychiatric disorders. It is hypothesized that the prevalence of CFS is higher than what has been found from clinically-based estimates. This study will be carried out in three stages. First, there will be an initial screening of a Chicago area sample. Respondents who meet CFS screening criteria will be followed up with a detailed structured psychiatric assessment. Stage three will involve a detailed medical history, physical exam, and laboratory tests. Univariate and multivariate statistical techniques will be utilized to delineate the overall rate of CFS in this Chicago population, its relative prevalence by gender, race/ethnicity, and social class, the prevalence of psychiatric comorbidity, and levels of functional impairment. Different definitions of CFS will be employed, and they will be compared and contrasted.

Thesaurus Terms: chronic fatigue syndrome, epidemiology

Institution: DE PAUL UNIVERSITY
Fiscal Year: 1999
Department: PSYCHOLOGY
Project Start: 01-JUN-1995
Project End: 31-MAY-2002
ICD: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
IRG: ZRG5

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ORTHOSTATIC INTOLERANCE IN CFS

Grant Number: 5R01HL059459-04
PI Name: FREEMAN, ROY
PI Title: ASSOCIATE PROFESSOR
Project Title: ORTHOSTATIC INTOLERANCE IN CFS

Abstract: DESCRIPTION (Adapted from the Investigator's Application): The over-all objectives of this proposal are: (1) to delineate the pathophysiology and pathogenesis of orthostatic intolerance in the chronic fatigue syndrome (CFS) (2) to investigate the role of orthostatic intolerance in producing the symptoms of CFS and (3) to use this information to apply physiologically appropriate therapeutic interventions and thereby decrease the symptoms of fatigue. The investigators plan to determine the physiological characteristics of orthostatic intolerance in CFS patients and healthy controls, characterize the differences in functional exercise capacity among CFS patients and between CFS patients and controls; and identify the relationships between the physiological measures of orthostatic intolerance, measures of functional exercise capacity, symptoms of orthostatic intolerance and symptoms of fatigue. Cardiovascular autonomic functions are to be assessed using standard tests of the sympathetic and parasympathetic nervous system; arterial baroreflex gain is to be measured using the heart rate and muscle sympathetic nerve activity response to pharmacological provocations; the cardiopulmonary baroreflex functions is to be assessed in response to graded central hypovolemia elicited by lower body negative pressure; plasma volume will be measured using the Evans Blue dye method; venous compliance assessed with venous occlusion plethysmography, Assessment of neurohumoral status and the functional exercise capacity is also to be included. These measures, which comprise the elements of orthostatic tolerance, will be compared with matched healthy controls. The relationships between these variables and the role of covariates such as the level of physical activity and psychiatric state, determined with standardized instruments, are to be analyzed using multivariate statistics.

Thesaurus Terms: chronic fatigue syndrome, fibromyalgia, pain threshold

Institution: BETH ISRAEL DEACONESS MEDICAL CENTER
Fiscal Year: 2001
Department:
Project Start: 01-FEB-1998
Project End: 31-JAN-2002
ICD: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
IRG: ZRG5

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AUTOANTIBODIES TO CELLULAR MATRIX ANTIGENS IN CFS

Grant Number: 5R01AI041033-04 PI Name: TAN, ENG M. PI Title: PROFESSOR AND HEAD Project Title: AUTOANTIBODIES TO CELLULAR MATRIX ANTIGENS IN CFS

Abstract: DESCRIPTION: (Adapted from Investigator's Abstract) On the basis of recent studies it has been shown that CFS sera contain antibodies to relatively insoluble cellular matrix antigens. Cellular structures (nuclear envelope, vimentin-containing intermediate filaments and a nuclear matrix particle visualized in immunofluorescence as reticulated speckles) associated with these antigens contain proteins that are part of the nuclear or cytoplasmic matrix. In collaboration with investigators at the University of Washington and at Harvard University, the PI and co-investigators at Scripps Research Institute will examine four research aims: 1) using previously collected blood samples from CFS patients from the two CFS center clinics and using currently developed assays the blood samples will be analyzed for the antibodies. They will be compared with patients with primary Sjogren's syndrome and primary fibromyalgia to determine whether differences in autoantibody specificities exist between different diseases and between CFS patients from different clinics; 2) ELISA assays will be developed for anti-lamin B1 and anti-vimentin using recombinant proteins expressed from cDNA clones, so that differences in antibody levels could be quantitated. This would be used in longitudinal studies of CFS patients to determine the role of humoral immunity in the natural history of the illness; 3) the possibility that there might be CFS-specific epitopes on lamin B1 and vimentin will be explored with expression products of PCR constructs, because if CFS-specific epitopes are detected, synthetic peptides of these regions could be used in highly specific immunological assays; 4) antibody screening of cDNA expression libraries will be performed to isolate the reticulated speckles nuclear antigen and a 45 kDa antigen. The antibody to the reticulated speckles could be a new or unique marker for CFS. The antibody to the 45 kDa antigen is present in Sjogren's syndrome but not in CFS-sicca and appears to be a distinguishing feature between the two clinical entities. Overall, these studies are aimed at rigorously defining autoantibody reactivities in CFS and may have etiologic implications.

Thesaurus Terms: autoantibody, chronic fatigue syndrome

Institution: SCRIPPS RESEARCH INSTITUTE
Fiscal Year: 2000
Department:
Project Start: 15-MAY-1997
Project End: 30-APR-2002
ICD: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
IRG: ZRG5

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DYSREGULATED 2-5A SYNTHETASE/RNASE L/PKR PATHWAYS IN CFS

Grant Number: 5R01AI038378-03
PI Name: SUHADOLNIK, ROBERT J.
PI Title: PROFESSOR
Project Title: DYSREGULATED 2-5A SYNTHETASE/RNASE L/PKR PATHWAYS IN CFS

Abstract: DESCRIPTION (Adapted from investigator's abstract): Research in the investigator's laboratory has focused on the two dsRNA-dependent IFN- inducible 2'5'oligoA synthetase/RNase L and PKR pathways. They have reported a statistically significant dysregulation in which the 2'5'A synthetase is present in its activated form, 2'5'A levels are elevated, RNase L is upregulated and the expression of PKR is downregulated. Recent data suggest additional differences unique to peripheral blood mononuclear cells (PBMC) from individuals with CFS compared to normal controls. Specifically, these findings in CFS PBMC are: 1) a 36kDa 2'5'A binding protein which is recognized by an RNase L polyclonal antibody; 2) a 90% decrease in cellular actin expression and 3) a pronounced change in total protein profiles. These data place the investigator in a unique position to explore the 2'5'A synthetase/RNase L and PKR systems in CFS. The proposed research will examine the 2'5'A synthetase and PKR pathways in an in vitro model and PBMC from a cohort of CFS patients and two control populations, in association with clinical symptomatology. The working hypothesis is that the characteristic signs and symptoms of CFS are associated with the dysregulation of the 2'5'A synthetase/RNase L and PKR pathways. The project will address: 1) the expression and activities of the four isoforms of 2'5'A synthetase; 2) the activators of 2'5'A synthetase; 3) the intracellular concentration, oligomer distribution and stability of 2'5'A; 4) the identification and characterization of the newly-discovered 36 kDa 2'5'A binding protein that is immunoreactive with RNase L antibody; 5) synthetic and natural routes for the inhibition of the upregulated RNase L in CFS; 6) the ultimate implications of the upregulated RNase L activity and 7) potential mechanisms for the decreased expression of PKR. The studies in the application are suggested to contribute to development of potential rational therapies for CFS.

Thesaurus Terms: chronic fatigue syndrome, enzyme activity, ligase, pancreatic ribonuclease

Institution: TEMPLE UNIVERSITY
Fiscal Year: 1999
Department: BIOCHEM AND MOLECULAR BIOLOGY
Project Start: 01-AUG-1997
Project End: 31-JUL-2001
ICD: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
IRG: ZRG5

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