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[Return to digest index] --------------------------------------------- This is a special digest of Co-Cure Research & Medical posts only Problems? Write to mailto:firstname.lastname@example.org --------------------------------------------- ---------------------------------------------------------------------- Date: Tue, 17 Apr 2007 15:44:37 -0400 From: "Bernice A. Melsky" <bernicemelsky VERIZON.NET> Subject: RES: Predictive value of brain perfusion SPECT for ketamine response in hyperalgesic fibromyalgia Predictive value of brain perfusion SPECT for ketamine response in hyperalgesic fibromyalgia. Eur J Nucl Med Mol Imaging. 2007 Mar 13; [Epub ahead of print] Guedj E, Cammilleri S, Colavolpe C, Taieb D, de Laforte C, Niboyet J, Mundler O. Service Central de Biophysique et de Medecine Nucleaire, Assistance Publique des Hopitaux de Marseille, Centre Hospitalo-Universitaire de la Timone, 264 rue Saint Pierre, 13385, Marseille Cedex 5, France, eric.guedj ap-hm.fr PMID: 17431615 PURPOSE: Ketamine has been used successfully in various proportions of fibromyalgia (FM) patients. However, the response to this specific treatment remains largely unpredictable. We evaluated brain SPECT perfusion before treatment with ketamine, using voxel-based analysis. The objective was to determine the predictive value of brain SPECT for ketamine response. METHODS: Seventeen women with FM (48 ± 11 years; ACR criteria) were enrolled in the study. Brain SPECT was performed before any change was made in therapy in the pain care unit. We considered that a patient was a good responder to ketamine if the VAS score for pain decreased by at least 50% after treatment. A voxel-by-voxel group analysis was performed using SPM2, in comparison to a group of ten healthy women matched for age. RESULTS: The VAS score for pain was 81.8 ± 4.2 before ketamine and 31.8 ± 27.1 after ketamine. Eleven patients were considered "good responders" to ketamine. Responder and non-responder subgroups were similar in terms of pain intensity before ketamine. In comparison to responding patients and healthy subjects, non-responding patients exhibited a significant reduction in bilateral perfusion of the medial frontal gyrus. This cluster of hypoperfusion was highly predictive of non-response to ketamine (positive predictive value 100%, negative predictive value 91%). CONCLUSION: Brain perfusion SPECT may predict response to ketamine in hyperalgesic FM patients. [Return to top] ------------------------------ Date: Tue, 17 Apr 2007 15:50:07 -0400 From: "Bernice A. Melsky" <bernicemelsky VERIZON.NET> Subject: RES: Abnormal brain processing of affective and sensory pain descriptors in chronic pain patients Abnormal brain processing of affective and sensory pain descriptors in chronic pain patients. J Affect Disord. 2007 Apr 13; [Epub ahead of print] Sitges C, Garcia-Herrera M, Pericas M, Collado D, Truyols M, Montoya P. Department of Psychology, University of Balearic Islands, Spain; Research Institute on Health Sciences (IUNICS), Palma, Spain. PMID: 17434596 OBJECTIVE: Previous research has suggested that chronic pain patients might be particularly vulnerable to the effects of negative mood during information processing. However, there is little evidence for abnormal brain processing of affective and sensory pain-related information in chronic pain. Behavioral and brain responses, to pain descriptors and pleasant words, were examined in chronic pain patients and healthy controls during a self-endorsement task. METHODS: Eighteen patients with fibromyalgia (FM), 18 patients with chronic musculoskeletal pain due to identifiable physical injury (MSK), and 16 healthy controls were asked to decide whether word targets described their current or past experience of pain. The number of self-endorsed words, elapsed time to endorse the words, and event-related potentials (ERPs) elicited by words, were recorded. RESULTS: Data revealed that chronic pain patients used more affective and sensory pain descriptors, and were slower in responding to self-endorsed pain descriptors than to pleasant words. In addition, it was found that affective pain descriptors elicited significantly more enhanced positive ERP amplitudes than pleasant words in MSK pain patients; whereas sensory pain descriptors elicited greater positive ERP amplitudes than affective pain words in healthy controls. CONCLUSIONS: These data support the notion of abnormal information processing in chronic pain patients, which might be characterized by a lack of dissociation between sensory and affective components of pain-related information, and by an exaggerated rumination over word meaning during the encoding of self-referent information about pain. [Return to top] ------------------------------ Date: Wed, 18 Apr 2007 12:55:34 -0400 From: Co-Cure Moderator <ray CO-CURE.ORG> Subject: MED: Why Doesn't My Doctor Know This? Why Doesn't My Doctor Know This? by Kent Holtorf, MD [Dr. Kent Holtorf, MD, is Medical Director of the Holtorf Medical Group Center for Hormone Imbalance, Hypothyroidism, and Fatigue in Torrance, California.* He specializes in treating CFS and FM patients.] A question that is often raised by patients is "Why doesn't my doctor know all of this?" The reason is that the overwhelming majority (all but a few percent) of physicians (endocrinologists, internists, family practitioners, rheumatologists, etc.) do not read medical journals. When asked, most doctors will claim that they routinely read medical journals, but this has been shown not to be the case. The reason is multi-factorial, but it comes down to the fact that the doctors do not have the time. They are too busy running their practices. The overwhelming majority of physicians rely on what they learned in medical school and on pharmaceutical sales representatives to keep them "up-to-date" on new drug information. Obviously, the studies brought to physicians for "educational purposes" are highly filtered to support their product. There has been significant concern by health care organizations and experts that physicians are failing to learn of new information presented in medical journals and lack the ability to translate that information into treatments for their patients. The concern is essentially that doctors erroneously rely on what they have previously been taught and don't change treatment philosophies as new information becomes available. This is especially true for endocrinological conditions, where physicians are very resistant to changing old concepts of diagnosis and treatment despite overwhelming evidence to the contrary, because it is not what they were taught in medical school and residency. Read the complete article at http://www.immunesupport.com/library/showarticle.cfm?id=7891 [Return to top] ------------------------------ Date: Thu, 19 Apr 2007 13:42:48 -0400 From: Fred Springfield <fredspringfield VERIZON.NET> Subject: RES: The prevalence of chronic fatigue syndrome in Nigeria The prevalence of chronic fatigue syndrome in Nigeria. Journal: Journal of Health Psychology, Vol. 12, No. 3, 461-474 (2007) Authors and affiliations: Mary Gloriac C. Njoku DePaul University, USA, nmgloria depaul.edu Leonard A. Jason DePaul University, USA Susan R. Torres-Harding Roosevelt University, USA NLM Citation: PMID: 17439996 The present study found adult rates of chronic fatigue syndrome (CFS) in Nigeria that were somewhat higher than rates from community-based CFS epidemiologic studies in the USA. The rates of chronic fatigue for both adults and children were also higher than in existing community-based studies. It is possible that the presence of several fatiguing illnesses such as malaria and typhoid, the lack of adequate healthcare resources and poverty in Nigeria, place individuals at greater risk for fatigue and its syndromes. There is a need for more epidemiologic studies on the prevalence and sociodemographic characteristics of CFS in developing countries. Key Words: Africa • community-based research • epidemiology • international study © 2007 SAGE Publications [Return to top] ------------------------------ Date: Thu, 19 Apr 2007 15:48:59 +0100 From: counsellingme3 <counsellingme YAHOO.CO.UK> Subject: Re: RES: The Infection Connection The Infection Connection - an article in Psychology Today http://psychologytoday.com/articles/index.php?term=pto-19990701-000031&page=1 "Now, decades later, infection has emerged as a prime suspect in psychological illnesses. The inadequacy of genetic and experiential explanations has prompted scientists to look elsewhere--and their gaze has come to rest on physical ailments, such as heart disease, cancers and ulcers, that in some cases have an infectious origin. Could the same be true, they wonder, for mental and emotional ills?" Peter Kemp [Return to top] ------------------------------ Date: Sat, 21 Apr 2007 11:58:09 +0200 From: "Dr. Marc-Alexander Fluks" <fluks COMBIDOM.COM> Subject: RES,NOT: Advances in Pain Research 2007 Source: NIH Date: April 2007 URL:   http://painconsortium.nih.gov http://edjassociates.com/pain2007/home.asp Pain Consortium Symposium: Advances in Pain Research 2007 --------------------------------------------------------- May 1, 2007 - NIH Masur Auditorium, Builing 10, Clinical Center, Bethesda The intent of the symposium is to present new and exciting advances in pain research and pain management, featuring work done through NIH support. Topics will include mechanisms and management of neuropathic pain, visceral pain, inflammatory pain, and treatment-induced pain. A poster session will include a broad selection of current pain research findings presented by young investigators. Members of the extramural scientific community, the NIH scientific community, health care providers, and the public are invited to attend. The event will be hosted by the co-Chairs of the NIH Pain Consortium. Symposium Location National Institutes of Health Masur Auditorium Building 10, Clinical Center Bethesda, MD 20892 The symposium will be videocast live and archived at http://videocast.nih.gov Parking on the NIH Campus is very limited. Please plan to take public transportation (the Metro subway system) or taxicabs to the Symposium. In addition, please have a government issued photo I.D., such as a driver's licenseor passport, which will be required to enter the campus. The Masur Auditorium is fully accessible-if you have special needs, please indicate these on the registration from, so that appropriate accommodations can be arranged. Registration Fee There is no charge to attend the symposium and it is open to the public. Registration for the Symposium General Attendees - Please register to attend the symposium. Go to the Registration page link. For assistance in locating hotel accommodations near the NIH campus, please click on the Hotel Information page. Federal Government Attendees - Please register to attend the symposium. Invited Speakers - Travel costs for invited speakers will be paid by EDJ Associates, Inc., contractor for NINDS. All speakers have been contacted directly by EDJ staff to facilitate travel arrangements. No registration on this site is needed. Invited Poster Presenters - Travel costs for poster presenters will be paid by EDJ Associates. All poster presenters have been contacted directly by EDJ staff to facilitate travel arrangements. No registration on this site is needed. We look forward to seeing you at the Pain Consortium Symposium: Advances in Pain Research 2007. If you have questions or comments about the Symposium, contact us at pain2007 edjassociates.com -------- (c) 2007 NIH [Return to top] ------------------------------ Date: Sat, 21 Apr 2007 13:58:37 -0400 From: "Bernice A. Melsky" <bernicemelsky VERIZON.NET> Subject: RES: Neck and back pain: musculoskeletal disorders Neck and back pain: musculoskeletal disorders. Neurol Clin. 2007 May;25(2):419-38. Meleger AL, Krivickas LS. Department of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, 125 Nashua Street, Boston, Massachusetts 02114, USA. PMID: 17445737 In this article, non-neurologic causes of neck and back pain are reviewed. Musculoskeletal pain generators include muscle, tendon, ligament, intervertebral disc, articular cartilage, and bone. Disorders that can produce neck and back pain include muscle strain, ligament sprain, myofascial pain, fibromyalgia, facet joint pain, internal disc disruption, somatic dysfunction, spinal fracture, vertebral osteomyelitis, and polymyalgia rheumatica. Atlantoaxial instability and atlanto-occipital joint pain are additional causes of neck pain. Back pain resulting from vertebral compression fracture, Scheuermann's disease, spondylolysis and spondylolisthesis, pregnancy, Baastrup's disease, sacroiliac joint dysfunction, and sacral stress fracture is discussed. [Return to top] ------------------------------ Date: Sat, 21 Apr 2007 13:58:04 +0200 From: "Dr. Marc-Alexander Fluks" <fluks COMBIDOM.COM> Subject: RES: CFS/ME & FM papers, published since March 2007 Source: NCBI PubMed Date: April 20, 2007 URL:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi Topic=((chronic fatigue) OR (myalgic encephalomyelitis)) OR fibromyalgia Ref: In the update, you will only find journals that are indexed by Medline (PubMed). All scientific papers 1938-today, http://www.me-net.combidom.com/library/literature.htm#publications http://www.me-net.combidom.com/library/literature.htm#catalogue Figures computer analysis scientific papers, http://www.me-net.combidom.com/library/literature.htm#figure All popular papers 1900-today, http://www.me-net.combidom.com/library/literature.htm#popular CFS/ME & FM papers, published since March 2007 ---------------------------------------------- ___ Njoku MG, Jason LA, Torres-Harding SR. The prevalence of chronic fatigue syndrome in Nigeria. J Health Psychol. 2007 May;12(3):461-74. ___ Van Hootegem H. Can homeopathy learn something from psychoanalysis? Homeopathy. 2007 Apr;96(2):108-12. ___ Guedj E, Cammilleri S, Colavolpe C, Taieb D, de Laforte C, Niboyet J, Mundler O. Predictive value of brain perfusion SPECT for ketamine response in hyperalgesic fibromyalgia. Eur J Nucl Med Mol Imaging. 2007 Mar 13. ___ Kuchinad A, Schweinhardt P, Seminowicz DA, Wood PB, Chizh BA, Bushnell MC. Accelerated brain gray matter loss in fibromyalgia patients: premature aging of the brain? J Neurosci. 2007 Apr 11;27(15):4004-7. ___ Gil Yubero J, Llensa Cubarsi I, Mas Marques M, Bunuel Alvarez JC. Comorbidity recorded in patients diagnosed with fibromyalgia at a primary care centre [Spanish]. Aten Primaria. 2007 Apr;39(4):217. ___ Heffez DS, Ross RE, Shade-Zeldow Y, Kostas K, Morrissey M, Elias DA, Shepard A. Treatment of cervical myelopathy in patients with the fibromyalgia syndrome: outcomes and implications. Eur Spine J. 2007 Apr 11. ___ Knoop H, Bleijenberg G, Gielissen MF, van der Meer JW, White PD. Is a full recovery possible after cognitive behavioural therapy for chronic fatigue syndrome? Psychother Psychosom. 2007;76(3):171-6. ___ Wyller VB. The chronic fatigue syndrome - an update. Acta Neurol Scand Suppl. 2007;187:7-14. ___ Clauw DJ. Fibromyalgia: Update on Mechanisms and Management. J Clin Rheumatol. 2007 Apr;13(2):102-109. ___ Arshad A, Ooi KK. Awareness and Perceptions of Fibromyalgia Syndrome: A Survey of Southeast Asian Rheumatologists. J Clin Rheumatol. 2007 Apr;13(2):59-62. ___ Repp ME. More points about fibromyalgia. Nursing. 2007 Apr;37(4):8. ___ Cook DB, O'connor PJ, Lange G, Steffener J. Functional neuroimaging correlates of mental fatigue induced by cognition among chronic fatigue syndrome patients and controls. Neuroimage. 2007 Mar 3. ___ Jones KD, Deodhar AA, Burckhardt CS, Perrin NA, Hanson GC, Bennett RM. A Combination of 6 Months of Treatment with Pyridostigmine and Triweekly Exercise Fails to Improve Insulin-Like Growth Factor-I Levels in Fibromyalgia, Despite Improvement in the Acute Growth Hormone Response to Exercise. J Rheumatol. 2007 Apr 1. ___ Garcia-Campayo J, Pascual A, Alda M, Gonzalez Ramirez MT. Coping with fibromyalgia: Usefulness of the Chronic Pain Coping Inventory-42. Pain. 2007 Mar 30. ___ Wyller VB, Due R, Saul JP, Amlie JP, Thaulow E. Usefulness of an abnormal cardiovascular response during low-grade head-up tilt-test for discriminating adolescents with chronic fatigue from healthy controls. Am J Cardiol. 2007 Apr 1;99(7):997-1001. ___ White PD, Sharpe MC, Chalder T, DeCesare JC, Walwyn R; PACE trial group. Protocol for the PACE trial: a randomised controlled trial of adaptive pacing, cognitive behaviour therapy, and graded exercise, as supplements to standardised specialist medical care versus standardised specialist medical care alone for patients with the chronic fatigue syndrome/myalgic encephalomyelitis or encephalopathy. BMC Neurol. 2007 Mar 8;7:6. ___ Kirsch A, Bernardy K. Fibromyalgia, Facial Expression and Emotional Experience. Psychopathology. 2007 Mar 29;40(4):203-208. ___ Kashikar-Zuck S, Lynch AM, Graham TB, Swain NF, Mullen SM, Noll RB. Social functioning and peer relationships of adolescents with juvenile fibromyalgia syndrome. Arthritis Rheum. 2007 Mar 29;57(3):474-480. ___ Arnold LM, Goldenberg DL, Stanford SB, Lalonde JK, Sandhu HS, Keck PE Jr, Welge JA, Bishop F, Stanford KE, Hess EV, Hudson JI. Gabapentin in the treatment of fibromyalgia: A randomized, double- blind, placebo-controlled, multicenter trial. Arthritis Rheum. 2007 Mar 28;56(4):1336-1344. ___ Muller W, Schneider M, Joos T, Hsu HY, Stratz T. Subgroups of fibromyalgia [German]. Schmerz. 2007 Mar 29. ___ Karper WB. Fibromyalgia, cognitive problems and independence: physical activity may be useful in home health care. Home Health Care Serv Q. 2007;26(1):19-28. ___ Ojima K, Watanabe N, Narita N, Narita M. Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population. Biopsychosoc Med. 2007 Jan 10;1:3. ___ Ullrich PM, Afari N, Jacobsen C, Goldberg J, Buchwald D. Cold pressor pain sensitivity in monozygotic twins discordant for chronic fatigue syndrome. Pain Med. 2007 May-Jun;8(3):216-22. ___ Evans WJ, Lambert CP. Physiological basis of fatigue. Am J Phys Med Rehabil. 2007 Jan;86(1 Suppl):S29-46. ___ Knoop H, Prins JB, Stulemeijer M, van der Meer JW, Bleijenberg G. The effect of cognitive behaviour therapy for chronic fatigue syndrome on self-reported cognitive impairments and neuropsychological test performance. J Neurol Neurosurg Psychiatry. 2007 Apr;78(4):434-6. ___ Taiwo OB, Russell IJ, Mignot E, Lin L, Michalek JE, Haynes W, Xiao Y, Zeitzer JM, Larson AA. Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome. Sleep Med. 2007 Apr;8(3):260-5. -------- (c) 2007 NCBI PubMed [Return to top] ------------------------------ Date: Sun, 22 Apr 2007 12:17:22 -0400 From: "Bernice A. Melsky" <bernicemelsky VERIZON.NET> Subject: RES: Pregabalin augmentation of quetiapine therapy in the treatment of fibromyalgia: an open-label, prospective trial Pregabalin augmentation of quetiapine therapy in the treatment of fibromyalgia: an open-label, prospective trial. Pharmacopsychiatry. 2007 Mar;40(2):68-71. Calandre EP, Morillas-Arques P, Rodriguez-Lopez CM, Rico-Villademoros F, Hidalgo J. Instituto de Neurociencias, Universidad de Granada, Granada, Spain. PMID: 17447176 INTRODUCTION: Quetiapine [U.S. brand name: Seroquel] has been shown to improve fibromyalgia symptoms, especially sleep disturbance, fatigue, morning stiffness, and mental well-being, but lacks an effect on pain. The purpose of this study was to evaluate if pregabalin [U.S. brand name: Lyrica], which has shown antialgic activity in fibromyalgia, added to quetiapine treatment additionally improved fibromyalgia symptomatology. METHODS: This was an open-label, 12-week study. Pregabalin was administered to 19 female fibromyalgia patients at a starting dose of 75 mg/day subsequently adjusted in according to the drug's efficacy and tolerability. Outcome measures included the Fibromyalgia Impact Questionnaire (FIQ), the Pittsburgh Sleep Quality Index, the Beck Depression Inventory, the State and Trait Anxiety Inventory, and the SF-12 Health Survey. RESULTS: Data analysis was done on the Intention-To-Treat sample which included 18 patients. Pregabalin significantly improved the pain and tiredness after awakening subscales of the FIQ as well as the physical component of the SF-12. Six patients withdrew from the study, 3 because of side effects. CONCLUSIONS: Our results suggest that the use of pregabalin can be a useful augmentation strategy in fibromyalgia patients partially responding to quetiapine. [Return to top] ------------------------------ Date: Mon, 23 Apr 2007 20:36:47 -0400 From: "Judith Wisdom <Wisdomjf@aol.com> via Co-Cure Moderator" Subject: Re: RES: Pregabalin augmentation of quetiapine therapy in the treatment of fibromyalgia: an open-label, prospective trial As one of the many ME/CFS patients who suffers terribly with pain I do want to warn people that the drug mentioned in this post (read the post at http://listserv.nodak.edu/cgi-bin/wa.exe?A2=ind0704d&L=co-cure&P=296) on CO-CURE might very well relieve some of the other rotten symptoms of fibromyalgia besides that of pain. If so it might still be worthwhile. BUT, please check out the frequent side effects of this drug in many: huge increase in appetite with concomitant fast weight gain and difficulty of staying away from offending foods AND, quite a bit more worrisome, is that like many psychotropics (especially those used to treat schizophrenia) it can cause tardive dyskinesia. That is a disorder of uncontrollable movement usually of the mouth and possibly tongue, which doesn't necessarily stop when the drug is. If you must take it, as with other drugs, you accept that risk; but those aren't risks that most people would like see happen to them (especially the latter). And abstracts about research into such drugs should also mention side effects not just main effects, since they are all effects of the drug, Seroquel/quetiapine. Those risks may be dose related and MAY be mitigated when used with Pregabalin, but the abstract doesn't say. Judith Wisdom [Return to top] ------------------------------
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