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[Return to digest index] --------------------------------------------- This is a special digest of Co-Cure Research & Medical posts only Problems? Write to mailto:email@example.com E-Mail mailto:Co-Cure-HMCfirstname.lastname@example.org to unsubscribe --------------------------------------------- ---------------------------------------------------------------------- Date: Tue, 8 May 2007 15:34:16 -0400 From: "Bernice A. Melsky" <bernicemelsky VERIZON.NET> Subject: RES: Prevalence of temporomandibular disorders in fibromyalgia and failed back syndrome patients: A blinded prospective comparison study Prevalence of temporomandibular disorders in fibromyalgia and failed back syndrome patients: A blinded prospective comparison study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 May 4; [Epub ahead of print] Balasubramaniam R, de Leeuw R, Zhu H, Nickerson RB, Okeson JP, Carlson CR. Former Resident, Orofacial Pain, Orofacial Pain Center, University of Kentucky. PMID: 17482850 OBJECTIVES: The objective of this study was to determine the prevalence of temporomandibular disorders (TMD) and evaluate psychosocial domains in patients with fibromyalgia (FM) compared with patients with failed back syndrome (FBS). STUDY DESIGN: The study included 51 (32 FM and 19 FBS) adult patients who were administered orofacial pain and psychological questionnaires before a clinical examination. Presence of TMD was diagnosed according to the Research Diagnostic Criteria for TMD. RESULTS: Fifty-three percent of the FM patients reported having face pain compared with 11% of the FBS patients. Of those FM patients who reported face pain, 71% fulfilled the criteria for a diagnosable TMD. FM patients had significantly higher subscale scores for somatization, obsessive-compulsive, medication used for sleep, and fatigue compared with FBS patients. Eighty-seven percent of the FM patients reported a stressful event and 42.3% had symptoms indicating posttraumatic stress disorder. CONCLUSION: The high prevalence of TMD and psychosocial dysfunction among FM patients suggests wide-reaching dysregulation of autonomic and hypothalamic-pituitary-adrenal axis functions. [Return to top] ------------------------------ Date: Wed, 9 May 2007 10:30:36 -0700 From: "Jodi Bassett <jodibassett bigpond.com> Subject: ACT, NOT, MED: The myths about M.E. and the symptoms of M.E. *permission to repost* The myths about M.E. and the symptoms of M.E. written by Jodi Bassett, May 2007 Because of the vast amount of inaccurate information being propagated about M.E. by various vested interest groups (helped immeasurably by the creation of a number of vague umbrella terms such as 'CFS' 'ME/CFS' 'CFS/ME' 'CFIDS' and Myalgic 'Encephalopathy' etc.) it is important to explain briefly what are the myths about M.E., and the symptoms of M.E. M.E. has nothing to do with being tired all the time. If you are very fatigued for an extended period of time this does not mean you are having a 'bout' of M.E. To suggest such a thing is no less absurd than to say that prolonged fatigue means you are having a 'bout' of multiple sclerosis, Parkinson's disease or Lupus. If you are constantly fatigued you do not have M.E. no matter how severe or prolonged your fatigue is. Fatigue is a symptom of many different illnesses as well as a feature of normal everyday life - but it is not a defining symptom of M.E., nor even an essential symptom of M.E. There are a number of post-viral fatigue states or fatigue syndromes which may follow common infections such as mononucleosis/glandular fever, hepatitis, Q fever, Ross river virus and so on. M.E. is an entirely different condition to these self-limiting fatigue syndromes however, the science is very clear on this point. People suffering with any of these post-viral fatigue states or fatigue syndromes do not have M.E. M.E. is also not the same condition as Lyme disease, athletes over-training syndrome, burnout, depression, somatisation disorder, candida, multiple chemical sensitivity syndrome or Fibromyalgia, or indeed any other illness. M.E. is a distinct neurological illness with a distinct; onset, symptoms, aetiology, pathology, response to treatment, long and short term prognosis - and World Health Organization classification (G.93.3). M.E. is also not defined by 'fatigue following exertion which can last up to 24 hours' as the bogus definitions of 'CFS' describe. Fatigue following activity (or post-exertional fatigue or malaise) is a common symptom of a large number of different illnesses - but what is happening in M.E. is quite different. Overexertion does not cause fatigue in M.E. but instead a worsening of the severity of the illness generally and of various neurological, cognitive, cardiac, cardiovascular, immunological, muscular and gastrointestinal (and other) symptoms. The severity of these symptoms can range from mild to severe to life-threatening. The effects of overexertion can last for hours, days, weeks or even many months in M.E., or can even be permanent. The onset of these post-exertional effects can be significantly delayed so that very often the worsening of the illness caused by overexertion has not even begun within 24 hours in M.E., let alone been completely resolved in that time. The reaction people with M.E. have to physical and mental activity, sensory input and orthostatic stress not only has nothing to do with mere fatigue (or 'malaise') but is in fact unique to M.E. in a number of ways. This reaction is so abnormal in fact that exercise testing is one of the series of tests which can be used to help confirm a M.E. diagnosis, as are various tests which measure the abnormal responses to orthostatic stress seen in M.E. This is simply not the case in post-viral fatigue syndromes, Lyme disease, Fibromyalgia and so on. These patient groups do not exhibit the same measurable pathological abnormalities as M.E. patients in these (and other) tests. Recent research has also shown that postural stress exacerbates cardiac insufficiency in M.E. and that this cardiac insufficiency is the cause of many of the symptoms and much of the disability of M.E. This pathology is also not seen in any of those illnesses causing fatigue after exertion which are commonly misdiagnosed as 'CFS.' The way people with M.E. respond to physical activity and orthostatic stress (etc.) is profoundly different than in these other illnesses; it is an entirely different problem, of a much greater magnitude. What defines M.E. is not 'chronic fatigue' but a specific type of acquired damage to the brain. M.E. is an acutely acquired illness with multi system involvement which is characterised by post encephalitic damage to the brain stem; a nerve centre through which many spinal nerve tracts connect with higher centres in the brain in order to control all vital bodily functions - this is always damaged in M.E. (Hence the name Myalgic Encephalomyelitis.) This diffuse brain injury is initiated by a virus infection which targets the brain; M.E. represents a major attack on the central nervous system (CNS) by the chronic effects of a viral infection. M.E. is an infectious and primarily neurological disease process which occurs in epidemic and sporadic forms, over 60 outbreaks of M.E. have been recorded worldwide since 1934. M.E. is primarily neurological, but because the brain controls all vital bodily functions every bodily system is affected and so symptoms can also be manifested by virtually all bodily systems including: cognitive, cardiac, cardiovascular, immunological, endocrinological, respiratory, hormonal, gastrointestinal and musculo-skeletal dysfunctions and damage. Symptoms are also caused by a loss of normal internal homeostasis in M.E.; the body/brain no longer responds appropriately to (to varying extents): physical activity, cognitive exertion, sensory input and orthostatic stress. At first glance a list of M.E. symptoms it may seem that every symptom possible is mentioned, but the seemingly random list of symptoms in fact form unique and distinct patterns - they are anything but 'random' for those with knowledge of the illness and/or of how the illness effects the body's various systems. Different people have a lot of different symptoms but the general pattern and evolution of major symptoms are remarkably coherent from patient to patient in M.E.; they fit a precise pattern that is nearly identical from one patient to the next. There is just no other illness that is even remotely like M.E. M.E. is a distinct, recognisable disease entity which contrary to popular belief is not difficult to diagnose and can in fact be diagnosed relatively early in the course of the disease (within just a few weeks) - providing that the physician has some experience with the illness. (The usual case of M.E. is so distinct that people with M.E. can recognise fellow sufferers almost in an instant.) Although there is (as yet) no single test which can be used to diagnose M.E. there are a series of tests which can confirm a suspected M.E. diagnosis. If all tests are normal, if specific abnormalities are not seen on certain of these tests (eg. brain scans), then a diagnosis of M.E. cannot be correct. (See Testing for Myalgic Encephalomyelitis for more information.) All of this is not simply theory, but is based upon an enormous body of clinical information which has been published in prestigious peer-reviewed journals all over the world and spans over 60 years. Confirmation of this hypothesis is supported by electrical tests of muscle and of brain function (including the subsequent development of PET and SPECT scans) and by biochemical and hormonal assays. Newer scientific evidence is increasingly strengthening this hypothesis. M.E. is neither 'mysterious' nor 'medically unexplained. Many aspects of the pathophysiology of the disease have, indeed, been medically explained in volumes of research articles. These are well-documented, scientifically sound explanations for why patients are bedridden, profoundly intellectually impaired, unable to maintain an upright posture and so on. M.E. affects all races and socio-economic groups and has been diagnosed all over the world with a similar strike rate to multiple sclerosis. Children as young as five can get M.E., as well as adults of all ages. M.E. can be extremely disabling. 25% of M.E. sufferers are severely affected and housebound and bedbound. In some cases Myalgic Encephalomyelitis can also be progressive, or fatal. Governments around the world are currently spending $0 a year on M.E. research. ------ Note 1: For more information about the medical and political facts of M.E. (and for references) see: Testing for Myalgic Encephalomyelitis, Putting Research and Articles into Context, The Ultra-comprehensive Myalgic Encephalomyelitis Symptom List and What is Myalgic Encephalomyelitis? ------ Note 2: Note that many different illnesses may share a percentage of the individual neurological, gastrointestinal or cognitive features of M.E., (and so on) but there is no other illness which encompasses each of the specific neurological, cognitive, immunological, gastrointestinal, cardiac and cardiovascular, endocrinological, respiratory, hormonal and other features and symptoms which make up M.E. This specific combination of symptoms is not seen in any other illness. There are also a number of characteristics of M.E. which are unique to the illness; most notably the way in which people with M.E. react to physical and mental activity, and orthostatic stress etc. and the way in which even low levels of these activities (beyond a person's individual limits) can negatively affect long-term prognosis. The acute onset of M.E. also sets it apart from many other illnesses commonly associated with a gradual onset, as do many other characteristics. See: M.E. and other illnesses and The misdiagnosis of CFS for more information. ------ Note 3: What is CFS? CFS was created in a response to an outbreak of what was unmistakably M.E., but this new name and definition did not describe the known signs, symptoms, history and pathology of M.E. It described a disease process that did not, and could not exist. All each of these flawed CFS definitions 'define' is a heterogeneous (mixed) population of people with various misdiagnosed psychiatric and miscellaneous non-psychiatric states which have little in common but the symptom of fatigue (a symptom seen in many illnesses but not a defining feature of M.E. nor even an essential symptom of M.E.). The disease category 'CFS' has undoubtedly been used to impose a false psychiatric paradigm of M.E. by allying it with various unrelated psychiatric fatigue states and post-viral fatigue syndromes (etc) for the benefit of various (proven) financial and political interests. CFS and M.E. are NOT the same. For more information on this topic, including how the CFS scam also negatively affects the media, doctors and the public etc., see: The misdiagnosis of CFS, Smoke and mirrors and Why the disease category of 'CFS' must be abandoned. The truth about the organic and distinct neurological illness M.E. must not be allowed to be buried under cover of 'fatigue' and 'CFS' for another 20 years! ------ www.ahummingbirdsguide.com Best wishes everyone, Jodi Bassett -- A Hummingbirds Guide to Myalgic Encephalomyelitis: www.ahummingbirdsguide.com -- Taking fatigue as the flagship symptom of a disease not only bestows the disease with a certain Rip Van Winkle humour, but it removes the urgency of the fact that the majority of [M.E.] symptoms are in effect CNS symptoms. To most physical [M.E.] scientists and clinicians, [M.E.] represents a major attack on the CNS by the chronic effects of a viral infection. Byron Hyde MD in 'The Clinical and Scientific basis of M.E. edited by Byron Hyde MD. p 11-12 -- [Return to top] ------------------------------ Date: Thu, 10 May 2007 13:06:55 -0400 From: "Bernice A. Melsky" <bernicemelsky VERIZON.NET> Subject: RES: Association between thyroid autoimmunity and fibromyalgic disease severity Association between thyroid autoimmunity and fibromyalgic disease severity. Clin Rheumatol. 2007 May 9; [Epub ahead of print] Bazzichi L, Rossi A, Giuliano T, De Feo F, Giacomelli C, Consensi A, Ciapparelli A, Consoli G, Dell'osso L, Bombardieri S. Division of Rheumatology, Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100, Pisa, Italy, l.bazzichi int.med.unipi.it PMID: 17487449 Our objectives were to investigate thyroid abnormalities and autoimmunity in 120 patients affected by fibromyalgia (FM) and to study their relationships with clinical data and symptoms. Thyroid assessment by means of antithyroglobulin antibodies, antithyroid peroxidase antibodies, free triiodo-thyronine, free thyroxine, and thyroid stimulating hormone analyses was carried out. The clinical parameters "Fibromyalgia Impact Questionnaire", pain, tender points, fatigue, and other symptoms, and the presence of depression or anxiety disorders were evaluated. The basal thyroid hormone levels of FM patients were in the normal range, while 41% of the patients had at least one thyroid antibody. Patients with thyroid autoimmunity showed a higher percentage of dry eyes, burning, or pain with urination, allodynia, blurred vision, and sore throat. Correlations found between thyroid autoimmunity and age or with the presence of depression or anxiety disorders were not significant. However, in the cohort of post-menopausal patients, the frequency of thyroid autoimmunity was higher with respect to pre-menopausal patients. In conclusion, autoimmune thyroiditis is present in an elevated percentage of FM patients, and it has been associated with the presence of typical symptoms of the disease. [Return to top] ------------------------------ Date: Fri, 11 May 2007 17:33:00 +0200 From: Jan van Roijen <j.van.roijen CHELLO.NL> Subject: act,med:ME/CFS -the Whittemore Peterson Institute ~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Send an Email for free membership ~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~ >>>> Help ME Circle <<<< >>>> 11 May 2007 <<<< Editorship : j.van.roijen chello.nl Outgoing mail scanned by Norton AV ~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~ http://www.krnv.com/Global/story.asp?S=6498357&nav=8faO NEWS4 RENO Chronic Fatigue Awareness Week Kicks Off May 12th May 10, 2007 In order to recognize the debilitating effects of Chronic Fatigue Syndrome (CFS) and call attention to the millions of families affected by the disease, May 12th - May 19th has been designated National Chronic Fatigue Syndrome Awareness Month. "This week presents a unique opportunity for us to create awareness about Chronic Fatigue Syndrome and rally support for a disease that is oftentimes forgotten and unrecognized in research and treatment circles," said Annette Whittemore, Founding Director of the Whittemore Peterson Institute for Neuro-Immune Disease. "We are thrilled that the Nevada legislature is giving us the opportunity to testify and rally support during this special month." The National Institute of Health reports CFS affects millions of individuals around the world with the largest single population of unmet medical need in the U.S. One out of every 300 Americans suffer from CFS, but currently there are no medications approved by the Food and Drug Administration for treating CFS. Full recovery is estimated at only 5-percent to 10-percent of all patients and CFS can be as disabling as multiple sclerosis, lupus, rheumatoid arthritis, congestive heart failure and similar chronic conditions. The estimated economic impact is $17-billion in lost income and an additional $7-billion in healthcare costs. Headquartered in the University of Nevada School of Medicine's Center for Molecular Medicine, which broke ground in early March 2007, the Whittemore Peterson Institute is the nation's first facility dedicated to the research and treatment of neuro-immune disease. The center is the first new medical research facility to be built at UNR in 20 years. "It is the mission of this institute to facilitate and advance patient care, research the patho-physiology and develop therapeutics, diagnostics and prevention strategies for a spectrum of neuro-immune diseases," Whittemore said. "This is a first-of-its-kind organization that fills a national healthcare void, treating patients that suffer from Chronic Fatigue Syndrome and other neuro-immune diseases." Annette Whittemore and others from the Whittemore Peterson Institute will testify at the Nevada Legislature in Carson City on Monday, May 14th at 9:00 am to gain further support for the institute and its mission. The general public is welcome to attend the hearing and show their support for this important cause at the Legislative Building, room 3137, in Carson City or log onto www.wpinstitute.org for more information. [Return to top] ------------------------------ Date: Fri, 11 May 2007 21:41:25 +0200 From: Jan van Roijen <j.van.roijen CHELLO.NL> Subject: not,res: Journal of Chronic Fatigue Syndrome - Current Contents ~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Send an Email for free membership ~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~ >>>> Help ME Circle <<<< >>>> 11 May 2007 <<<< Editorship : j.van.roijen chello.nl Outgoing mail scanned by Norton AV ~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~ Current Contents with Abstracts for Journal of Chronic Fatigue Syndrome ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Volume 13, Issue 4 Editor(s): Kenny De Meirleir , MD, PhD Neil R. McGregor , BDS, MDSc, PhD Elke Van Hoof , ClinPsy, PhD This issue is now available online and will soon be mailed to subscribers in approximately 4-6 weeks. NOTE: If the URLs in this email are not active hyperlinks, copy and paste the URL into the address/location box in your browser. TABLE OF CONTENTS EDITORIAL Elke Van Hoof, Kenny De Meirleir, Neil McGregor http://www.haworthpress.com/store/ArticleAbstract.asp?ID=91460 Conservation of Resources and Quality of Life in Individuals with Chronic Fatigue Syndrome René R. Taylor, Supriya Kulkarni, Yukiko Shiraishi http://www.haworthpress.com/store/ArticleAbstract.asp?ID=91461 Antiviral Pathway Deregulation of Chronic Fatigue Syndrome Induces Nitric Oxide Production in Immune Cells That Precludes a Resolution of the Inflammatory Response Marc Frémont, Freya Vaeyens, C. Vincent Herst, Kenny De Meirleir, Patrick Englebienne http://www.haworthpress.com/store/ArticleAbstract.asp?ID=91463 Long-Term Treatment with a Staphylococcus Toxoid Vaccine in Patients with Fibromyalgia and Chronic Fatigue Syndrome Carl-Gerhard Gottfries, Ove Häger, Björn Regland, Olof Zachrisson http://www.haworthpress.com/store/ArticleAbstract.asp?ID=91464 Reliability of a Chronic Fatigue Syndrome Questionnaire Caroline Hawk Hines, Leonard A. Jason, Susan R. Torres-Harding http://www.haworthpress.com/store/ArticleAbstract.asp?ID=91465 Lyme Disease Presenting as Chronic Fatigue Syndrome Samuel Shor http://www.haworthpress.com/store/ArticleAbstract.asp?ID=91467 Depression, Chronic Fatigue Syndrome, and Fibromyalgia: An Update Kenneth R. Kaufman, Paul J. Goodnick http://www.haworthpress.com/store/ArticleAbstract.asp?ID=91468 Journal of Chronic Fatigue Syndrome is published both in print and electronically. Library subscribers may be entitled to electronic site wide access with paid subscriptions. For more information go to http://www.haworthpress.com/journals/libraryonlinejour.asp or contact email@example.com For more information about the journal: http://www.haworthpress.com/store/Product.asp?sku=J092 [Return to top] ------------------------------ Date: Fri, 11 May 2007 18:41:49 -0400 From: Fred Springfield <fredspringfield VERIZON.NET> Subject: RES: Conservation of Resources and Quality of Life in Individuals with Chronic Fatigue Syndrome Conservation of Resources and Quality of Life in Individuals with Chronic Fatigue Syndrome Journal: Journal of Chronic Fatigue Syndrome, Vol. 13, Issue 4 (2006), Pub Date: 4/5/2007, Page Range: 5 - 18 Contributors and affiliations: René R. Taylor PhD, Associate Professor, Licensed Clinical Psychologist, Department of Occupational Therapy , University of Illinois at Chicago, Chicago, IL, 60612 Supriya Kulkarni MS, OTR/L, Graduate Student, Department of Occupational Therapy, University of Illinois at Chicago Yukiko Shiraishi PhD, Project Coordinator, Department of Occupational Therapy, University of Illnois at Chicago Abstract: Objective: To examine the relationship between resources and quality of life in individuals with chronic fatigue syndrome (CFS). Participants and Study Design: A cross-sectional design was used to describe associations between resource loss and gain and quality of life for 47 individuals diagnosed with CFS. Main Outcome Measures: The Conservation of Resources Evaluation was used to measure resources in terms of perceived loss and gain. Health-related quality of life was assessed with the Quality of Life Index. Results: Total resource loss and total resource gain were significant correlates of overall quality of life. Gains in self-esteem, energy, and work resources were associated with higher-perceived quality of life. Material loss and energy loss were associated with lower-perceived quality of life. Conclusions: Findings for the relationships between perceived resources of self-esteem, work, material items, and energy and perceived quality of life can be used inform future rehabilitation efforts. These relationships appear to occur independently of illness severity among individuals CFS. [Return to top] ------------------------------ Date: Sat, 12 May 2007 04:16:22 -0400 From: Fred Springfield <fredspringfield VERIZON.NET> Subject: RES: Antiviral Pathway Deregulation of Chronic Fatigue Syndrome Induces Nitric Oxide Production in Immune Cells That Precludes a Resolution of the Inflammatory Response Antiviral Pathway Deregulation of Chronic Fatigue Syndrome Induces Nitric Oxide Production in Immune Cells That Precludes a Resolution of the Inflammatory Response Journal: Journal of Chronic Fatigue Syndrome, Volume: 13 Issue: 4 (2006), Page Range: 17 - 28, Pub Date: 4/5/2007 Contributors and affiliations: Marc Frémont PhD, RED Laboratories, Brussels, B-1731, Belgium Freya Vaeyens MS, RED Laboratories N.V., Brussels, B-1731, Belgium C. Vincent Herst PhD, RED Laboratories N.V., Brussels, B-1731, Belgium Kenny De Meirleir MD, PhD, Department of Human Physiology and Medicine, Vrije Universiteit Brussel, Brussels, B-1051, Belgium Patrick Englebienne PhD, Department of Nuclear Medicine, Free University of Brussels, Brugmann Hospital, Brussels, B-1020, Belgium, firstname.lastname@example.org Abstract: Chronic fatigue syndrome (CFS) is a poorly defined medical condition diagnosed by exclusion, which, besides severe chronic fatigue as the hallmark symptom, involves inflammatory and immune activation stigma. Although viral infections are not systematically found in CFS patients, the type I interferon antiviral pathway has been repeatedly shown to be activated in peripheral blood mononuclear cells (PBMC) of the most afflicted patients. An abnormal truncated form of ribonuclease L (37-kDa RNase L) is also found in the PBMC of CFS patients and this protein has been proposed as a biological marker for CFS. Recently, the levels of this abnormal protein have been significantly correlated to the extent of inflammatory symptoms displayed by CFS patients. We report here that active double-stranded RNA-dependent kinase (PKR) is expressed and activated in parallel to the presence of the 37-kDa RNase L and to an increase in nitric oxide production by immune cells. However, PKR upregulation results also in a significant increase followed by a decrease in caspase 3 activity for the samples containing the highest levels of 37-kDa RNase L. This caspase 3 downregulation does not result from increased expression of the anti-apoptotic proteins Bcl-2 and Bcl-XL. These results therefore suggest that chronic inflammation due to excess nitric oxide production plays a role in CFS and that the normal resolution of the inflammatory process by NF-kB activation and apoptotic induction is impaired. These observations draw new directions for the therapeutic approach of CFS. Keywords: RNase L pathway, nitric oxide, PKR, chronic inflammation [Return to top] ------------------------------ Date: Sun, 13 May 2007 19:47:53 +0200 From: ME/CFS <me_cfs GLOCALNET.NET> Subject: RES: Epigenetic hypothesis about ME EPIGENETIC HYPOTHESIS ABOUT ME I believe that ME might be caused by epigenetic changes. Many patients report that they are converted into the ME state over one night. Maybe that is achieved by cells being reprogrammed by changes in the phenotype (epigenetic layer). That means that for example a methyl group has attached (or left) the DNA at specific places, resulting into the gene sequence to be switched off (or on). Stress or infection may be the trigger of such a change of phenotype. Maybe hypothalamus (and/or other parts of the body pertaining to the neuro endocrine immune system) is put into a different mode (reprogrammed) by such a change of phenotype. If epigenetic is a part of ME, than ME research needs to involve specialists in epigenetics. It is not sufficient to look at messenger molecules as for example cytokines, neuropeptides and hormones. It is necessary to also study the signal system that triggers epigenetic changes. If the people undergo epigenetic changes, then their bodies might no longer obey biomedical laws valid for healthy people. This means that scientific knowledge about bodily processes for healthy persons, may be invalid for a person with an epigenetic change. Thus, one can not assume that a biochemical process in a healthy person would be the same in a person with an epigenetic change. /Kasper Ezelius, M.Sc., Sweden (http://goto.glocalnet.net/me_cfs) Some links about epigenetics: http://en.wikipedia.org/wiki/Epigenetics#_note-choi06 http://discovermagazine.com/2006/nov/cover http://www.epigenome.org/index.php https://notes.utk.edu/Bio/greenberg.nsf/0/b360905554fdb7d985256ec5006a7755?O penDocument http://www.epigeneticsnews.com/ [Return to top] ------------------------------ Date: Mon, 14 May 2007 19:49:06 -0400 From: Fred Springfield <fredspringfield VERIZON.NET> Subject: RES: Long-Term Treatment with a Staphylococcus Toxoid Vaccine in Patients with Fibromyalgia and Chronic Fatigue Syndrome Long-Term Treatment with a Staphylococcus Toxoid Vaccine in Patients with Fibromyalgia and Chronic Fatigue Syndrome Journal: Journal of Chronic Fatigue Syndrome, Volume: 13 Issue: 4, Page Range: 29 - 40 (2006) Pub Date: 4/5/2007 Authors and affiliations: Carl-Gerhard Gottfries MD, PhD, Professor Emeritus, Institute of Clinical Neuroscience, University of Gothenburg, Sahlgren University Hospital, Mölndal, Sweden, <email@example.com> Ove Häger, Research Nurse, Institute of Clinical Neuroscience, University of Gothenburg, Sweden, <firstname.lastname@example.org> Björn Regland MD, PhD, Assistant Professor, Institute of Clinical Neuroscience, University of Gothenburg, Sweden, <email@example.com> Olof Zachrisson MD, PhD, Institute of Clinical Neuroscience, University of Gothenburg, Sweden, <firstname.lastname@example.org> One hundred and sixty patients with fibromyalgia and chronic fatigue syndrome, who were on a continuous treatment with a Staphylococcus vaccine, were followed during one year with repeated consultation visits. The patients had participated in controlled studies and been on continuous treatment with the vaccine for 22 ±10 months before inclusion into this follow-up study. They were treated with 1 mL of the vaccine subcutaneously every third to fourth week. Adverse events were few. The adherence to the treatment was very good. Over a period of one year, 8% withdrew, and in only 5%, the withdrawal was due to insufficient clinical effect. Only in two cases where the patients were allergic to the preservative of the vaccine, the side effects caused the withdrawal of the treatment. Ratings with scales (CPRS-15 and FibroFatigue) showed improvement from start of treatment and also further improvement during the follow-up year. In view of the natural history for these disorders the result is of interest. Keywords: Fibromyalgia, chronic fatigue syndrome, Staphylococcus vaccine, long-term treatment [Return to top] ------------------------------
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